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Your Vote Counts! AGILE THERAPEUTICS, INC. 2021 Annual Meeting Vote by June 7, 2021 11:59 PM ET C/O BROADRIDGE P.O BOX 1342 BRENTWOOD, NY 11717 D49508-P56571 You invested in AGILE THERAPEUTICS, INC. and it’s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the stockholder meeting to be held on June 8, 2021. Get informed before you vote View the Notice and Proxy Statement and Form 10-K online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 25, 2021. If you would like to request a copy of the material(s) for this and/or future stockholder meetings, you may (1) visit www.ProxyVote.com, (2) call 1-800-579-1639 or (3) send an email to sendmaterial@proxyvote.com. If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. Smartphone users Point your camera here and vote without entering a control number Vote Virtually at the Meeting* June 8, 2021 9:00 AM, EDT Virtually at: www.virtualshareholdermeeting.com/AGRX2021 *Please check the meeting materials for any special requirements for meeting attendance. V1 For complete information and to vote promptly, visit www.ProxyVote.com Control #

Vote at www.ProxyVote.com THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming stockholder meeting. Please follow the instructions on the reverse side to vote these important matters. Board Recommends Voting Items D49509-P56571 Prefer to receive an email instead? While voting on www.ProxyVote.com, be sure to click “Sign up for E-delivery”. 1. Election of Directors Nominees: 01) Al Altomari 02) John Hubbard, Ph.D., FCP 03) James P. Tursi, M.D. For 2. The approval, on a non-binding, advisory basis, of the 2020 compensation of our named executive officers. For 3. Ratify the appointment of Ernst & Young LLP as the Company’s independent registered public accounting firm for the year ending December 31, 2021. For NOTE: Such other business as may properly come before the meeting or any adjournment thereof.